An international airline flight full of passengers disappears out of thin air with now explanation. The pilot, Rayford Steele, finds out that his plane is not the only group to instantly vanish from the face of the earth. His wife and son are among the missing. Millions of people worldwide vanish and so Steele and a group of survivors decided to take matters into their own hands and find out who or what is responsible and why the chosen "millions" have been take away. As the group get deeper into the mystery, they find out the answers could be found in a book more than two centuries old or on a videotape in an abandoned church...who knows.