When an evil spore is awakened by global warming after lying dormant for eons beneath an ancient ice field, a horrific plague ravages mankind, sending Meadow on the run from crumbling civilization. She gets a lift from a stranger, notices the driver is gruesomely infected, and escapes, taking refuge in an abandoned cabin...but is it abandoned? Now, ten strangers attempt to evade the madness in a small town, with some succumbing to the hideously mutating fungus -- and claiming the survivors as their bitter prey.