Barbara Stanwyck stars as a once respectable and vibrant wife who has become a desperately out-of-control high roller in The Lady Gambles. A chance visit into a Las Vegas casino introduces Joan Booth (Stanwyck) to the seductive allure of poker and the craps table. All too soon, she ignores her devoted husband (Robert Preston) and older sister (Edith Barrett) as she compulsively chases after hard-hearted Lady Luck.